Sex differences in the response to influenza virus infection: modulation by stress.
Identifieur interne : 001514 ( Main/Exploration ); précédent : 001513; suivant : 001515Sex differences in the response to influenza virus infection: modulation by stress.
Auteurs : Ronit Avitsur [Israël] ; Jacqueline W. Mays ; John F. SheridanSource :
- Hormones and behavior [ 1095-6867 ] ; 2011.
Descripteurs français
- KwdFr :
- Animaux, Caractères sexuels, Comportement alimentaire (physiologie), Comportement animal (physiologie), Contention physique (médecine vétérinaire), Contention physique (physiologie), Contention physique (psychologie), Corticostérone (sang), Expression des gènes, Femelle, Infections à Orthomyxoviridae (génétique), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (physiopathologie), Infections à Orthomyxoviridae (sang), Interleukine-1 bêta (génétique), Interleukine-6 (génétique), Mâle, Orthomyxoviridae (immunologie), Orthomyxoviridae (physiologie), Souris, Souris de lignée C57BL, Stress psychologique (génétique), Stress psychologique (immunologie), Stress psychologique (physiopathologie), Stress psychologique (sang).
- MESH :
- génétique : Infections à Orthomyxoviridae, Interleukine-1 bêta, Interleukine-6, Stress psychologique.
- immunologie : Infections à Orthomyxoviridae, Orthomyxoviridae, Stress psychologique.
- médecine vétérinaire : Contention physique.
- physiologie : Comportement alimentaire, Comportement animal, Contention physique, Orthomyxoviridae.
- physiopathologie : Infections à Orthomyxoviridae, Stress psychologique.
- psychologie : Contention physique.
- sang : Corticostérone, Infections à Orthomyxoviridae, Stress psychologique.
- Animaux, Caractères sexuels, Expression des gènes, Femelle, Mâle, Souris, Souris de lignée C57BL.
English descriptors
- KwdEn :
- Animals, Behavior, Animal (physiology), Corticosterone (blood), Feeding Behavior (physiology), Female, Gene Expression, Interleukin-1beta (genetics), Interleukin-6 (genetics), Male, Mice, Mice, Inbred C57BL, Orthomyxoviridae (immunology), Orthomyxoviridae (physiology), Orthomyxoviridae Infections (blood), Orthomyxoviridae Infections (genetics), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (physiopathology), Restraint, Physical (physiology), Restraint, Physical (psychology), Restraint, Physical (veterinary), Sex Characteristics, Stress, Psychological (blood), Stress, Psychological (genetics), Stress, Psychological (immunology), Stress, Psychological (physiopathology).
- MESH :
- chemical , blood : Corticosterone.
- chemical , genetics : Interleukin-1beta, Interleukin-6.
- blood : Orthomyxoviridae Infections, Stress, Psychological.
- genetics : Orthomyxoviridae Infections, Stress, Psychological.
- immunology : Orthomyxoviridae, Orthomyxoviridae Infections, Stress, Psychological.
- physiology : Behavior, Animal, Feeding Behavior, Orthomyxoviridae, Restraint, Physical.
- physiopathology : Orthomyxoviridae Infections, Stress, Psychological.
- psychology : Restraint, Physical.
- veterinary : Restraint, Physical.
- Animals, Female, Gene Expression, Male, Mice, Mice, Inbred C57BL, Sex Characteristics.
Abstract
Influenza virus infection is a significant public health problem; however factors affecting the incidence and severity of disease have not been fully elucidated. The present study sought to examine the role of sex and stress in mediating susceptibility to an influenza viral infection in mice. Male and female mice underwent repeated cycles of restraint (RST) stress, followed by an influenza A/PR8 virus infection. Following these manipulations, levels of circulating corticosterone, lung proinflammatory cytokine gene expression and sickness behavior were examined. The data indicate sex differences in several aspects of the response to the A/PR8 virus infection. The kinetics of lung interleukin-1β mRNA expression were faster in infected males compared to females, while circulating corticosterone levels were elevated in infected females, but not in males. Anorexia and reduced saccharin consumption began earlier and symptoms were more pronounced in infected males than in females. In addition, RST modulated the response to the A/PR8 virus infection. Proinflammatory cytokine gene expression in response to infection was enhanced and sickness behavior was modulated by RST in both males and females. These data suggest that males mount more vigorous immune and behavioral responses to influenza viral infection compared to females, and stress exacerbates the response in both males and females. In conclusion, complex interactions between biological and behavioral factors are involved in mediating individual differences in health and disease. Additional studies may help uncover some of the factors contributing to the individual differences in susceptibility to influenza infection.
DOI: 10.1016/j.yhbeh.2010.12.002
PubMed: 21167165
Affiliations:
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Le document en format XML
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The present study sought to examine the role of sex and stress in mediating susceptibility to an influenza viral infection in mice. Male and female mice underwent repeated cycles of restraint (RST) stress, followed by an influenza A/PR8 virus infection. Following these manipulations, levels of circulating corticosterone, lung proinflammatory cytokine gene expression and sickness behavior were examined. The data indicate sex differences in several aspects of the response to the A/PR8 virus infection. The kinetics of lung interleukin-1β mRNA expression were faster in infected males compared to females, while circulating corticosterone levels were elevated in infected females, but not in males. Anorexia and reduced saccharin consumption began earlier and symptoms were more pronounced in infected males than in females. In addition, RST modulated the response to the A/PR8 virus infection. Proinflammatory cytokine gene expression in response to infection was enhanced and sickness behavior was modulated by RST in both males and females. These data suggest that males mount more vigorous immune and behavioral responses to influenza viral infection compared to females, and stress exacerbates the response in both males and females. In conclusion, complex interactions between biological and behavioral factors are involved in mediating individual differences in health and disease. Additional studies may help uncover some of the factors contributing to the individual differences in susceptibility to influenza infection.</div></front></TEI><affiliations><list><country><li>Israël</li></country></list><tree><noCountry><name sortKey="Mays, Jacqueline W" sort="Mays, Jacqueline W" uniqKey="Mays J" first="Jacqueline W" last="Mays">Jacqueline W. Mays</name><name sortKey="Sheridan, John F" sort="Sheridan, John F" uniqKey="Sheridan J" first="John F" last="Sheridan">John F. Sheridan</name></noCountry><country name="Israël"><noRegion><name sortKey="Avitsur, Ronit" sort="Avitsur, Ronit" uniqKey="Avitsur R" first="Ronit" last="Avitsur">Ronit Avitsur</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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